does dna methylation plays a critical role in osteoblastic differentiation of mesenchymal stem cells (mscs)?

نویسندگان

najmaldin saki research center of thalassemia and hemoglobinopathy, jundishapur university of medical sciences, ahvaz, ir iran

majid farshdousti hagh hematology and oncology research center, tabriz university of medical sciences, tabriz, ir iran; hematology and oncology research center, tabriz university of medical sciences, tabriz, ir iran, tel: +98-4113364665, fax: +98-4113364665

esmaeil mortaz division of pharmacology, utrecht institute for pharmaceutical sciences, utrecht university, utrecht, netherlands

abdolreza ardeshiry lajimi young researchers club, science and research branch, islamic azad university, tehran, ir iran

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منابع مشابه

Does DNA Methylation Plays a Critical Role in Osteoblastic Differentiation of Mesenchymal Stem Cells (MSCs)?

1 Research Center of Thalassemia and Hemoglobinopathy, Jundishapur University of Medical Sciences, Ahvaz, IR Iran 2 Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran 3 Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands 4 Young Researchers Club, Science and Research Branch, Islamic Azad U...

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Evaluation of Changes in Global DNA Methylation during Osteoblastic Differentiation of Mesenchymal Stem Cells: A Laboratory Study

Background and Objectives: Control processes in osteoblastic differentiation of mesenchymal stem cells are not yet fully understood. Epigenetic mechanisms, especially the methylation of CpG Islands in the promoter of genes, are considered as one of the most important control mechanisms in stem cell differentiation. In the process of differentiation, it is debated whether only the methylation of...

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different methylation patterns of runx2, osx, dlx5 and bsp in osteoblastic differentiation of mesenchymal stem cells

objective: runt-related transcription factor 2 (runx2) and osterix (osx) as two specific osteoblast transcription factors and distal-less homeobox 5 (dlx5) as a non-specific one are of paramount importance in regulating osteoblast related genes including osteocalcin, bone sialoprotein (bsp), osteopontin and collagen type iα1. the present study sets out to investigate whether epigenetic regulati...

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ror2 promoter methylation change in osteoblastic differentiation of mesenchymal stem cells

objective: osteoblasts arise from multipotent mesenchymal stem cells (mscs) present in the bone marrow stroma and undergo further differentiation to osteocytes or bone cells. many factors such as proteins present in the wnt signaling pathway affect osteoblast differentiation. ror2 is an orphan tyrosine kinase receptor that acts as a co-receptor in the non-canonical wnt signaling pathway. howeve...

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Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells.

Mutations in the NF1 tumor suppressor gene cause neurofibromatosis type 1, a pandemic autosomal dominant genetic disorder with an incidence of 1:3000. Individuals with NF1 have a variety of malignant and non-malignant manifestations, including skeletal manifestations, such as osteoporosis, scoliosis and short statures. However, the mechanism(s) underlying the osseous manifestations in NF1 are p...

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تاثیر داروی زولدرونیک اسید در بیان و متیلاسیون ژن BSP در طول تمایز استئوبلاستیک سلولهای بنیادی مزانشیمی

Background and Aim: Bone sialoprotein (BSP) is a specific marker of osteoblastic differentiation. In this research, the effect of Zoledronic Acid on BSP expression and methylation status during osteoblastic differentiation of mesenchymal stem cells (MSCs) was evaluated. Materials and Methods: In this experimental study, MSCs were isolated from human bone marrow. For osteogenic differentiation,...

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عنوان ژورنال:
iranian red crescent medical journal

جلد ۱۵، شماره ۸، صفحات ۷۵۵-۷۵۶

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